Wheat germ, both fermented and unfermented, has been a part of the human diet for millennia with no indication that it poses any health hazards. Avemar™ is produced from wheat germ. A loaf of whole-wheat bread containing about 2 cups of whole-wheat flour (∼270 g) includes about 7 g of wheat germ. Wheat germ is also used as an ingredient in a wide variety of foods formulated to provide advantageous nutritional characteristics without any adverse effects.

The fermented wheat germ in Avemar™ pulvis is substantially equivalent to the fermented wheat germ found in whole-wheat food. Historically safe consumption of whole-wheat products also provides strong evidence of the safety of Avemar™ pulvis for its intended use.